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What is the main reason why there was an American Civil War?

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Best Answer - Chosen by Asker: Causes of the American Civil War: A Summary

There were a series of significant events which greatly affected States' Rights, the Union, African Americans and accelerated the American Civil War. These historical events are commonly referred to as the "Causes of the American Civil War" and are listed without significant order: States' Rights (Bill of Rights and the 10th Amendment), High Tariffs, Nullification Crisis, Missouri Compromise, Kansas-Nebraska Act, Manifest Destiny, Dred Scott Case, Fugitive Slave Act of 1850, Bleeding Kansas, Crittenden Compromise, John Brown, and President Abraham Lincoln's election (Lincoln didn't receive a single Southern electoral vote).