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Question: Who were the leaders of the federalists and anti-federalists!?
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The answer will depend on whether you're referring to the period when the Constitution was being considered for ratification, or the period of the Washington and Adams administrations!.

Hamilton, Jay, and James Madisonwere responsible for writing the Federalist papers, which argued the reasons for voting for the Constituion!. Patrick Henry was one opponent!.

During the above mentioned presidencies, Hamilton, Adams, Washington were Federalists, while Jefferson was the leading anti-federalist!.Www@QuestionHome@Com

Leaders among the Federalists included two men who helped develop the Constitution, JAMES MADISON and ALEXANDER HAMILTON, and two national heroes whose support would greatly improve the Federalists' prospects for winning, GEORGE WASHINGTON and BENJAMIN FRANKLIN!.

The Anti-Federalists believed that each state should have a sovereign, independent government!. Their leaders included some of the most influential figures in the nation, including PATRICK HENRY and GEORGE MASON!.Www@QuestionHome@Com